CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF CONDENSED AZACYCLES (CANNABINOID RECEPTOR MODULATORS)

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专利权人:

ARENA PHARMACEUTICALS; INC.

发明人:

BLACKBURN, ANTHONY C.,HAN, SANGDON,JONES, ROBERT M.,PAL, BIMAN B.,RUETER, JAIMIE KARYN,MONTALBAN, ANTONIO GARRIDO

申请号：

MYPI 2013003122

公开号：

MY165767A

申请日:

2012.02.24

申请国别(地区):

MY

年份:

2018

代理人:

摘要：

THE PRESENT INVENTION RELATES TO CRYSTALLINE FORMS OF (1AS,5AS)-2-(4-OXY-PYRAZIN2-YI)- 1A,2,5,5A- TETRAHYDRO- 1H-2,3-DIAZA-CYCLOPROPA[A]PENTALENE-4-CARBOXYIIC ACID ((S)- 1 AHYDROXYMETHYL-2,2- DIMETHYL-PROPYL)-AMIDE (COMPOUND 1) AND PHARMACEUTICAL COMPOSITIONS THEREOF THAT MODULATE THE ACTIVITY OF THE CANNABINOID CB2 RECEPTOR AND ARE THEREFORE USEFUL IN THE TREATMENT OF CB2 RECEPTOR-MEDIATED DISORDERS, FOR EXAMPLE, OSTEOARTHRITIS； PAIN； HYPERALGESIA； ALLODYNIA； INFLAMMATORY HYPERALGESIA； NEUROPATHIC HYPERALGESIA； ACUTE NOCICEPTION； OSTEOPOROSIS； MULTIPLE SCLEROSIS-ASSOCIATED SPASTICITY； AUTOIMMUNE DISORDERS； ALLERGIC REACTIONS； CNS INFLAMMATION FOR EXAMPLE； ATHEROSCLEROSIS； UNDESIRED IMMUNE CELL ACTIVITY, AND INFLAMMATION ASSOCIATED WITH A DISORDER SELECTED FROM: OSTEOARTHRITIS, ANAPHYLAXIS, BEHCET’S DISEASE, GRAFT REJECTION. VASCULITIS, GOUT, SPONDYLITIS, VIRAL DISEASE, BACTERIAL DISEASE, IUPUS, INFLAMMATORY BOWEL DISEASE, AUTOIMMUNE HEPATITIS, AND TYPE 1 DIABETES MELLITUS； AGE-RELATED MACULAR DEGENERATION； COUGH； LEUKEMIA； LYMPHOMA； CNS TUMORS； PROSTATE CANCER； ALZHEIMER’S DISEASE； STROKE-INDUCED DAMAGE； DEMENTIA； AMYOTROPHIC LATERAL SCLEROSIS； AND PARKINSON’S DISEASE. (FIGURE 1)

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中国工程科技知识中心

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