您的位置：
首页
>
农业专利
>
详情页
CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF CANNABINOID RECEPTOR MODULATORS
- 专利权人:
- Arena Pharmaceuticals; Inc.
- 发明人:
- Anthony C. Blackburn,Sangdon Han,Robert M. Jones,Antonio Garrido Montalban,Biman B. Pal,Jaimie Karyn Rueter
- 申请号：
- US16214388
- 公开号：
- US20190308952A1
- 申请日:
- 2018.12.10
- 申请国别(地区):
- US
- 年份:
- 2019
- 代理人:
- 摘要：
- The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor and are therefore useful in the treatment of CB2 receptor-mediated disorders, for example, osteoarthritis； pain； hyperalgesia； allodynia； inflammatory hyperalgesia； neuropathic hyperalgesia； acute nociception； osteoporosis； multiple sclerosis-associated spasticity； autoimmune disorders； allergic reactions； CNS inflammation for example； atherosclerosis； undesired immune cell activity, and inflammation associated with a disorder selected from: osteoarthritis, anaphylaxis, Behcet's disease, graft rejection, vasculitis, gout, spondylitis, viral disease, bacterial disease, lupus, inflammatory bowel disease, autoimmune hepatitis, and type 1 diabetes mellitus； age-related macular degeneration； cough； leukemia； lymphoma； CNS tumors； prostate cancer； Alzheimer's disease； stroke-induced damage； dementia； amyotrophic lateral sclerosis； and Parkinson's disease.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
