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CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF CONDENSED AZACYCLES
- 专利权人:
- 发明人:
- BLACKBURN ANTHONY C,HAN SANGDON,JONES ROBERT M,MONTALBAN ANTHONY GARRIDO,PAL BIMAN B,RUETER JAIMIE KARYN
- 申请号：
- IN7768/DELNP/2013
- 公开号：
- IN2013DN07768A
- 申请日:
- 2013.09.04
- 申请国别(地区):
- IN
- 年份:
- 2016
- 代理人:
- 摘要：
- The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)- 1a,2,5.5a-tetrahydro- 1 H-2,3-diaza- cyclopropa[a]pentalene-4-carboxylic acid ((S)- 1 - hydroxymcthyl-2.2-dimcthyl-propyl)-amidc (Compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor and are therefore useful in t treatment of CB2 receptor-mediated disorders, for example, osteoarthritis pain hyperalgesia allodynia inflammatory hyperalgesia neuropathic hyperalgesia acute nociception osteoporosis multiple sclerosis-associated spasticity autoimmune disorders allergic reactions CNS inflammation for example atherosclerosis undesired immune cell activity, and inflammation associated with a disorder selected from: osteoarthritis, anaphylaxis, Behcets disease, graft rejection, vasculitis, gout, spondylitis, viral disease, bacterial disease, lupus, inflammatory bowel disease, autoimmune hepatitis, and type 1 diabetes mellitus age-related macular degeneration cough leukemia lymphoma CNS rumors prostate cancer Alzheimers disease stroke-induced damage dementia amyotrophic lateral sclerosis and Parkinsons disease.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
