N-(PYRIDIN-2-YL)-4-(THIAZOL-5-YL)PYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC COMPOUNDS

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专利权人:

UNIVERSITY OF SOUTH AUSTRALIA

发明人:

Shudong WANG,Solomon Tadesse ZELEKE,Mingfeng YU

申请号：

US15749652

公开号：

US20180222900A1

申请日:

2016.08.04

申请国别(地区):

US

年份:

2018

代理人:

摘要：

A novel class of inhibitors of protein kinases that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain, central nervous system, colorectal cancer and leukaemias. The inhibitors have the general structure I:

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