The present invention relates to immunological compositions and vaccines that target diseases caused by infection with Streptococcus pyogenes. In particular, the compositions of the present invention find use in therapeutic and/or prophylactic methods for the treatment or prevention of morbidity associated with infection with Streptococcus pyogenes. The present invention also relates to methods of making the immunological compositions and vaccines as well as methods for producing stable SpeAB antigen formulations in combination with one or more additional immunologically active substituents (e.g., adjuvants).
