UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXANE-QUINAZOLINE AND -LINKED DIOXANE-QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF

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专利权人:

BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

发明人:

Qiang Zhang,Hongbo Zhang,Leifu Yang,Hailong Yang,Likai Zhou,Nanqiao Zheng,Shannan Yu,Zhongxiang Wang,Shouye Feng,Zhanqiang Xu

申请号：

US16489989

公开号：

US20200061065A1

申请日:

2018.02.11

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention relates to a urea-substituted aromatic ring-linked dioxinoquinazoline and a urea-substituted aromatic ring-linked dioxinoquinoline of Formula (I), or a pharmaceutically acceptable salt thereof or a hydrate thereof. Also provided are the preparation of the compound as shown in Formula (I) and the pharmaceutically acceptable salt thereof and the use thereof as a drug. The drug is used as an inhibitor of tyrosine kinases (e.g., VEGFR-2, C-RAF, B-RAF) for treating tyrosine kinase-related diseases.

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