The invention relates to compounds of the formula (I): wherein ring C is as defined herein, for example indolyl, indazolyl or azaindolyl Z is -O-, -NH- or -S- n is 0-5 m is 0-3 R1 and R2 are defined herein including groups: (i) Q1X1 wherein Q1 and X1 are as defined herein (ii) Q15W3 wherein Q15 and W3 are as defined herein, (iii) Q21W4C1-5alkylX1- wherein Q21, W4 and X1 are as defined herein, (iv) Q28C1-5alkylX1-, Q28C2-5alkenylX1- or Q28C2-5alkynylX1- wherein Q28 and X1 are as defined herein and (v) Q29C1-5alkylX1-, Q29C2-5alkenylX1- or Q29C2-5alkynylX1- wherein Q29 and X1 are as defined herein R2 can also be 6,7-methylenedioxy or 6,7-ethylenedioxyand salts thereof their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm
