Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof

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专利权人:

Beijing Scitech-MQ Pharmaceuticals Limited

发明人:

Zhang, Qiang,Zhang, Hongbo,Yang, Leifu,Yang, Hailong,Zhou, Likai,Zheng, Nanqiao,Yu, Shannan,Wang, Zhongxiang,Feng, Shouye,Xu, Zhanqiang

申请号：

AU2018226922

公开号：

AU2018226922A1

申请日:

2018.02.11

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

The present invention relates to a urea-substituted aromatic ring-linked dioxane-quinazoline compound of formula (1) and a urea-substituted aromatic ring-linked dioxane-quinoline, or a pharmaceutically acceptable salt thereof or a hydrate thereof. Also provided are the preparation of the compound as shown in formula (1) and the pharmaceutically acceptable salt thereof and the use thereof as a drug. The drug is used as an inhibitor of tyrosine kinases (e.g., VEGFR-2, C-RAF, B-RAF) for treating tyrosine kinase-related diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/