Comprising applying to the skin tissue an effective amount of a composition comprising a carrier being a dermatologically acceptable, aged skin, for example, the appearance of the peri-menopausal, menopausal, or skin and postmenopausal S- palmitoyl glutathione makeup how to improve.S-パルミトイルグルタチオンおよび皮膚科学的に許容される担体を含む組成物の有効量を皮膚組織に適用することを含む、老化皮膚、例えば閉経前後の、閉経期の、または閉経後の皮膚の外観を改善する化粧方法。