Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a composition comprising an effective amount of N-Acetyl-Tyrosinamide and an effective amount of a retinoid, in a cosmetically acceptable vehicle, for topical application to the skin for a time sufficient to improve the appearance of said skin.本發明提供用於預防、改善或減輕皮膚老化跡象之方法,其使用於化妝品上可接受之媒劑中包含有效量之N-乙醯基-酪胺醯胺及有效量之類視黃素的組合物,用於局部施用至皮膚上持續足以改善該皮膚之外觀的時間。