Disclosed herein is a unit dosage form comprising a thin water-soluble film matrix, wherein said film matrix comprises (a) a polyvinyl alcohol-polyethylene glycol graft copolymer as a water-soluble matrix polymer (b) an active ingredient being a steroidal estrogen selected from the group of:9alpha-Vinyl-estra-1,3,5(10)-triene-3,16alpha-diol, 17beta-Fluoro-9alpha-vinyl-estra-1,3,5(10)-triene-3,16alpha-diol, 18alpha-Homo-9alpha-vinyl-estra-1,3,5(10)-triene-3,16alpha-diol, 16alpha-Fluoro-8beta-vinyl-estra-1,3,5(10)-triene-3,17alpha-diol, 16alpha-Fluoro-8beta-vinyl-estra-1,3,5(10)-triene-3,17beta-diol, 16beta-Fluoro-8beta-vinyl-estra-1,3,5(10)-triene-3,17beta-diol, 8beta-Vinyl-estra-1,3,5(10)-triene-3,17beta-diol, including therapeutically acceptable derivatives thereof andsaid film matrix has a thickness of less than 300 microns,wherein said film matrix may also comprise at least a further water-soluble matrix polymer selected from the group of a cellulosic material, a synthetic polymer, a gum, a protein, a starch, a glucan and mixtures thereof.
