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Dual and single layer dosage forms
专利权人:
Siew Lian Chung;Hock Seng Tan
发明人:
Hock Seng Tan,Siew Lian Chung
申请号:
US13060325
公开号:
US09017718B2
申请日:
2010.04.22
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Provided is a dual-release, dual-adhesiveness flexible thin film dosage form comprising: a quick-release subfilm comprising an admixture of polymer, which comprises predominantly highly water-soluble polymer(s), and a bioactive agent, the polymers and other components of the quick-release subfilm adapted to provide 20 minutes or less erodibility for the quick-release subfilm; and laminated against the quick-release subfilm, a sustained-release subfilm comprising an admixture of polymer, which comprises predominantly hydrophilic, bioadhesive polymer(s), and a second bioactive agent, which can be the same as the first, the polymers and other components of the sustained-release subfilm adapted to provide erodibility of 1 hour or more and 20 hours or less for the sustained-release subfilm, the dosage form having a thickness of 30 mil or less, and being more adhesive on the sustained-release side.
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中国工程科技知识中心
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