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ABUSE RESISTANT DRUG FORMS
专利权人:
发明人:
Mark Tengler,Russell McMahen
申请号:
US14128750
公开号:
US20140127300A1
申请日:
2012.07.02
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention is directed to oral drug dosage forms designed to reduce the abuse potential of an oral dosage form of an opioid analgesic. The oral drug dosage form comprises a first population of drug-resin complex particles comprising an analgesically effective amount of an opioid drug, said first population of particles coated with a water-permeable diffusion barrier coating. The oral drug dosage form further comprises a second population of ion exchange-resin complex particles comprising an aversive agent, said second population of particles coated with a polymer coating sufficient to substantially prevent release of the aversive agent under normal use conditions. The aversive agent is present in an amount effective to partially or substantially deny the drug abuser the euphoric effect and/or cause an aversive effect in the user.
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