Henderik Willem FRIJLINK,Niel GRASMEIJER,Wouter Leonardus Joseph HINRICHS,Katie Ingrid Eduard AMSSOMS,Lieven Elvire Colette BAERT
申请号：
US15501425
公开号：
US20170231916A1
申请日:
2015.08.03
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to dosage forms comprising a compressed blend of a biologically active ingredient, one or more polymers like a poly(a-hydroxy carboxylic acid) in which optionally is incorporated a glass transition modifying agent, and optional further ingredients, wherein the polymer or polymeric mixture has a specific glass transition temperature which causes the system to be in the glassy state at ambient conditions before administration and to be in the rubbery state under the physiological conditions to which the system is exposed after administration, resulting in pulsed release of said biologically active ingredient.
