BRAIN, CHRISTOPHER THOMAS,CHO, YOUNG SHIN,GIRALDES, JHON WILLIAM,LAGU, BHARAT,LEVELL, JULIAN,LUZZIO, MICHAEL,PEREZ, LAWRENCE BLAS,WANG, YAPING,YANG, FAN
申请号：
PE0012592012
公开号：
PE18152012A1
申请日:
2011.02.17
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to compounds pirrolo - pyrimidine Derivatives of formula (i) where a is CH or N l is a Link, C (o) or s (OR) 2 r1 is alkyl, cycloalkyl (C3 - C7) (C3 - C7) optionally substituted alkyl (C1 - C6) or o phenyl optionally substituted by alkyl (C1 - C6), C (CH3) 2cn u Oh, among others R11 is H or alkyl (c1-c4) r2y is a compound of formula (a), (b), among others.Where V is NH or CH2 R4 is H, deuterium, C (R5) - (r6) - (R7), where R5, R6, R7, R8, R9 and R10 are each H or deuterium. Preferred compounds are: ciclopentil - 2 - (5 - (1, 5, 7, 9 - hydroxy - trimethyl - 3.7 - 1,4-diazabicyclo [3.3.1] - - - - - Nonan 3 carbonyl) pyridin-2-yl - amino) - n, n-dimethyl - 7h pyrrolo [2,3-d] - pyrimidine - 6 - carboxamide Dimethyl amide acid ciclopentil - 7 - 8 - [5 - (2 - methyl - 3.8 - Grabarsky, ITs The Wrong Guy Bicyclo [3.2.1 - - 3 - carbonyl] octan-3-yl pyridin-2-yl) - amino] - 7h pyrrolo [2,3-d] - pyrimidine - 6 - 7 - ciclopentil - carboxylic acid n, N - dimethyl - 2 - (5 - ((3aS, 6aR) - 1 - [oxohexahidro pyrrolo - 3,4-c] pyrrole - 2 (1H) - yl) - (pyridin-2-yl) - amino - 7h pyrrolo [2,3-d] - pyrimidine - 6 - carboxamide among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of Cyclin Dependent Kinases 4 and 6 (Cdk4 \/ 6) to be useful in the treatment of cancerSE REFIERE A COMPUESTOS DERIVADOS DE PIRROLO-PIRIMIDINA DE FORMULA (I) DONDE A ES CH O N L ES UN ENLACE, C(O) O S(O)2 R1 ES ALQUILO(C3-C7), CICLOALQUILO(C3-C7) OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6) O OH, FENILO OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6), C(CH3)2CN U OH, ENTRE OTROS R11 ES H O ALQUILO(C1-C4) R2Y ES UN COMPUESTO DE FORMULA (a), (b), ENTRE OTROS, EN DONDE V ES NH O CH2 R4 ES H, DEUTERIO, C(R5)-(R6)-(R7), EN DONDE R5, R6, R7, R8, R9 Y R10 SON CADA UNO H O DEUTERIO. SON COMPUESTOS PREFERIDOS: CICLOPENTIL-2-(5-(9-HIDROXI-1,5,7-TRIMETIL-3,7-DIAZABICICLO-[3.3.1]-NONAN-3-CARBONIL)-PIRIDIN-2-IL-AMINO)-N,N-DIMETIL-7H-PIRROLO-[2,3-d]-PIRIMIDIN-6-CARBOXAMIDA DIMETIL-AM
