NOVARTIS AG;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人:
FRAIETTA, JOSEPH A.,MELENHORST, JAN J.
申请号：
CA3057306
公开号：
CA3057306A1
申请日:
2018.03.22
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention provides compositions and methods improved CAR T cell therapies. Specifically, the invention provides cells with altered expression and/or function of one or more genes, e.g., associated with Tet2, and methods of use therefore. The invention further provides inhibitors of the one or more genes and methods of use therefore in connection with CAR T cells.
