The Trustees of the University of Pennsylvania;Gregory MOTZ;Joseph A. FRAIETTA;Carl H. JUNE;Frederic Dixon BUSHMAN;Christopher Loren NOBLES;Jan J. MELENHORST;Novartis AG
发明人:
Gregory Motz,Frederic Dixon Bushman,Joseph A. Fraietta,Carl H. June,Jan J. Melenhorst,Christopher Loren Nobles,Regina M. Young
申请号：
US15760519
公开号：
US20180258149A1
申请日:
2016.09.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides compositions and methods improved CAR T cell therapies. Specifically, the invention provides cells with reduced Tet, e.g., Tet2 function or expression, and methods of use therefore. The invention further provides Tet2 inhibitors and methods of use therefore in connection with CAR T cells.
