STRANSKA, Denisa,KLABANOVA, Adela,DOLEZAL, Pavel,VRBATA, Petr,BERKA, Pavel,MUSILOVA, Marie
申请号：
ES11819049
公开号：
ES2763952T3
申请日:
2011.12.12
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A vehicle for the oromucosal administration of physiologically active substances, characterized in that it contains at least one elastic layer (1) of polymer nanofibers conformable according to the shape of a selected wall of the oral cavity to which it should be applied, in which the layer polymer nanofiber elastic (1) comprises a releasable drug and / or other physiologically active substance in which the elasticity and conformability of the polymer nanofiber layer provides contact of the layer with the selected wall of the oral cavity, allowing thus a good penetration of the drug and / or other physiologically active substance into this wall, or a possible transfer through it to the vascular system and to human or animal organisms, in which the operability and elasticity of the nanofiber layer is provided due to to the production of a layer of nanofibers through electrostatic needleless spinning, in which simultaneously with a polymer also a drug and / or other physiologically active substances are spun, which are then releasably deposited in the nanofiber layer, and in which the carrier further comprises a non-adhesive oromucosally practicable and elastic covering layer (2) on one side of the vehicle while the other side of the polymer nanofiber layer remains free and by means of it the vehicle can be fixed on the selected wall of the oral cavity.Un vehículo para la administración oromucosal de sustancias fisiológicamente activas, caracterizado porque contiene al menos una capa elástica (1) de nanofibras de polímero conformables de acuerdo con la forma de una pared seleccionada de la cavidad bucal a la que debe aplicarse, en que la capa elástica (1) de nanofibras de polímero comprende un fármaco liberable y / u otra sustancia fisiológicamente activa en que la elasticidad y capacidad de conformación de la capa de nanofibras de polímero proporciona el contacto de la capa con la pared seleccionada de la cavidad bucal, permitiendo así una buena penetración del fárma
