Barbara Bertani;Susanna Cremonesi;Stefano Fontana;Alessandra Pasquarello
发明人:
Barbara Bertani,Susanna Cremonesi,Stefano Fontana,Alessandra Pasquarello
申请号：
US12680792
公开号：
US08217168B2
申请日:
2008.10.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to novel compounds of formula (I) or a salt thereof:whereinG is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8- to 11-membered heteroaryl bicyclic group；p is an integer ranging from 0 to 5；R1 is halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5； or corresponds to a group R6； and when p is an integer ranging from 2 to 5, each R1 may be the same or different；R2 is hydrogen or C1-4alkyl；n is 3, 4, 5 or 6；R6 is a moiety selected from the group consisting of: isoxazolyl, —CH2—N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such R6 group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl；R4 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C1-4alkyl, C3-7 cycloalkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and NR′R″； or R4 is a phenyl group, a 5-14 membered heterocyclic group； and any of such phenyl or heterocyclic group is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5；R7 is hydrogen or C1-2alkyl；R′ is H, C1-4 alkyl or C1-4 alkanoyl；R″ is defined as R′；R′ and R″ taken together with the interconnecting nitrogen atom may form a 5-, 6-membered saturated or unsaturated heterocyclic ring；and their use in therapy, as modulators of dopamine D3 receptors.
