598703 Disclosed is a recombinant adenovirus derived from a recombinant adenovirus plasmid vector, wherein the recombinant adenovirus plasmid vector comprises a nucleotide sequence encoding: a Plasmodium circumsporozoite protein gene, or antigenic portion thereof, operably linked to a heterologous promoter sequence, and one or more modified capsid and/or core protein genes, wherein an immunogenic epitope sequence of Plasmodium circumsporozoite has been inserted into or replaces at least part of the one or more capsid or core protein genes and wherein the immunogenic epitope sequence is a B cell epitope sequence selected from (NANP)12, (NANP)14, (NANP)16, (NANP)18, (NANP)20, or (NANP)22. Further disclosed is a recombinant adenovirus derived from a recombinant adenovirus plasmid vector, wherein the recombinant adenovirus plasmid vector comprises a nucleotide sequence encoding: a Plasmodium circumsporozoite protein gene, or antigenic portion thereof, operably linked to a heterologous promoter sequence, and one or more modified capsid and/or core protein genes, wherein an immunogenic epitope sequence of Plasmodium circumsporozoite has been inserted into or replaces at least part of the one or more capsid and/or core protein genes and wherein the core protein gene comprises ap VII protein gene and a CD4+ T cell epitope sequence is inserted into the p VII protein gene.
