KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人:
KIM, Bo Yeon,김보연,SAKCHAISRI, Krisada,삭차이스리크리사다,KIM, Sun Ok,김선옥,NARAGANAHALLI, Ramegowda Thimmegowda,나라가나할리라메고우다띠메오고단,SOUNG, Nak Kyun,성낙균,AHN, Jong Seog,안종석,HWANG, Joonsung,황준성,RYOO, In Ja,류인자,JANG, Ja
申请号：
KRKR2013/008084
公开号：
WO2014/038894A1
申请日:
2013.09.06
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention relates to ethyl(2-methyl-3{(E)-[(naphtha[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, which is a novel inhibitor for cell mitosis. The ethyl(2-methyl-3{(E)-[(naphtha[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate inhibits tubulin polymerization during mitosis to thus induce apoptosis. Furthermore, the acetate has excellent effects in cancer cells having multidrug resistance. Therefore, the acetate can be effectively used to treat cell proliferative disorders including various cancers.La présente invention concerne le (2-méthyl-3{(E)-[(naphta[2,1-b]furan-2-ylcarbonyl)hydrazono]méthyl}-1H- indole-1-yl)acétate déthyle, qui est un nouvel inhibiteur de la mitose cellulaire. Le (2-méthyl-3{(E)-[(naphta[2,1-b]furan-2-ylcarbonyl)hydrazono]méthyl}-1H- indole-1-yl)acétate déthyle inhibe la polymérisation de tubuline pendant la mitose pour ainsi induire lapoptose. De plus, lacétate décrit ci-dessus a dexcellents effets dans les cellules cancéreuses ayant une résistance multiple aux médicaments. En conséquence, lacétate peut être utilisé de façon efficace pour traiter divers troubles de la prolifération cellulaire tels que le cancer.본 발명은 신규한 세포 유사분열 저해제인 에틸(2 - 메틸 - 3 - {(E) - [(나프타[2,1-b]퓨란-2-일카보닐)하이드라조노]메틸} - 1H - 인돌 - 1 - 일)아세테이트에 관한 것이다. 에틸(2 - 메틸 - 3 - {(E) - [(나프타[2, 1 - b]퓨란 - 2 - 일카보닐)하이드라조노]메틸} - 1H - 인돌 - 1 - 일)아세테이트는 유사분열 과정에서 튜불린의 중합을 저해하여 세포자살을 유도한다. 또한 다제약 내성을 보이는 암세포에도 효과가 우수하다. 따라서 다양한 암을 비롯한 세포증식성 질병의 치료에 중요하게 이용될 수 있다.
