Bo Yeon Kim,Krisada Sakchaisri,Sun Ok Kim,Ramegowda Thimmegowda Naraganahalli,Nak Kyun Soung,Jong Seog Ahn,Joonsung Hwang,In Ja Ryoo,Jae-Hyuk Jang
申请号：
US14641065
公开号：
US20150182502A1
申请日:
2015.03.06
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.
