Benzoyl-piperidine derivatives as dual modulators of 5-HT2A and D3 receptors

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专利权人:

エフ．ホフマン－ラ;アーゲー;ロシュ;エフ.ホフマン-ラ ロシュ アーゲー

发明人:

ゴッビ，ルカ,ヤーシュケ，ゲオルク,ロドリゲス・サルミエント，ロサ・マリア,スチュワード，ルシンダ,ゴッビ,ルカ,ヤーシュケ,ゲオルク,ロドリゲス・サルミエント,ロサ・マリア,スチュワード,ルシンダ

申请号：

JP2010519432

公开号：

JP5296073B2

申请日:

2008.07.30

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine； 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.

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中国工程科技知识中心

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