Luca Gobbi,Georg Jaeschke,Rosa Maria Rodriguez Sarmiento,Lucinda Steward
申请号：
US12184272
公开号：
US08097637B2
申请日:
2008.08.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds of formula (I)wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
