The present invention provides compound of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds:wherein n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, R20, X, Y, Q and Z have defined meanings.本發明提供式(I)之化合物,其作為p53-MDM2交互作用抑制劑的用途,以及作為包含該化合物之醫藥組成物:其中n、m、p、s、t、R1、R2、R3、R4、R5、R6、R7、R20、X、Y、Q和Z具有經過定義之意義。