NEW SPIRO[3H-INDOLE-3,2-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS农业专利-农业学术服务平台

发明人:: RAMHARTER, JUERGEN,雷哈特吉尔金,雷哈特吉爾金,BROEKER, JOACHIM,布鲁克乔奇姆,布魯克喬奇姆,GILLE, ANNIKA,吉列安妮卡,吉列安妮卡,GOLLNER, ANDREAS,戈纳安德亚斯,戈納安德亞斯,HENRY, MANUEL,翰瑞曼纽,翰瑞曼紐,TOELLE, NINA,托勒妮娜,托勒妮娜,WEINSTABL, HARALD,威斯

摘要：: The present invention encompasses compounds of formula (I) wherein the groups R1 to R7, A, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.本發明涵蓋式(I)化合物其中基團R1至R7、A、V、W、X、Y、n、r及q如技術方案1中所定義;其作為MDM2-p53相互作用抑制劑之用途;含有此類化合物之醫藥組合物;其作為藥劑、尤其作為用於治療及/或預防致癌疾病之藥劑的用途;及合成中間物。