NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS

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专利权人:

Boehringer Ingelheim International GmbH

发明人:

Andreas GOLLNER,Joachim BROEKER,Nina KERRES,Christiane KOFINK,Juergen RAMHARTER,Harald WEINSTABL,Annika GILLE,Stefan GOEPPER,Manuel HENRY,Guenther HUCHLER

申请号：

US16003232

公开号：

US20180273541A1

申请日:

2018.06.08

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention encompasses compounds of formula (I)wherein the groups R1 to R4, R7, A, D, E, F, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.

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