The present invention relates to a Lactuca sativa L. var. longifolia Lam seed designated as 41-49 RZ, which has leaves with a hollow main vein, broad base leaves, and exhibits resistance against downy mildew (Bremia lactucae Regel), currant-lettuce aphid (Nasonovia ribisnigri), corky root (Sphingomonas suberifaciens) and lettuce mosaic virus (LMV). The present invention also relates to a Lactuca sativa L. var. longifolia Lam plant produced by growing the “41-49 RZ” seed. The invention further relates to methods for producing the lettuce cultivar, represented by lettuce variety 41-49 RZ.
