The present invention relates to a Lactuca sativa L. var. longifolia Lam seed designated as 41-53 RZ, which has leaves with a solid main vein, narrow base leaves, and exhibits resistance against downy mildew (Bremia lactucae Regel), currant-lettuce aphid (Nasonovia ribisnigri) and lettuce mosaic virus (LMV). The present invention also relates to a Lactuca sativa L. var. longifolia Lam plant produced by growing the “41-53 RZ” seed. The invention further relates to methods for producing the lettuce cultivar, represented by lettuce variety 41-53 RZ.
