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含磷活性物質的立體選擇性合成
专利权人:
GILEAD PHARMASSET LLC
发明人:
ROSS, BRUCE, S.,SOFIA, MICHAEL, JOSEPH,PAMULAPATI, GANAPATI, REDDY,RACHAKONDA, SUGUNA,ZHANG, HAI-REN
申请号:
HK15100071.5
公开号:
HK1199645A
申请日:
2015.01.06
申请国别(地区):
HK
年份:
2015
代理人:
摘要:
Disclosed herein is a process for preparing an enantiomerically- or a diastereomerically enriched phosphorus-containing active, salt, or pharmaceutically acceptable salt thereof, of formula I-1 , which comprises the steps of: (a) reacting a protected or unprotected Active with a base to form a salt of said active and then reacting said salt with an enantiomerically- or a diastereomerically enriched compound of formula II-1 wherein the Active is a nucleoside, a nucleoside-analog, or a non-nucleoside.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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