Krystaliczny 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1-(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian (S)-izopropylu

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专利权人:

Gilead Pharmasset LLC

发明人:

ROSS, BRUCE S.,SOFIA, MICHAEL JOSEPH,PAMULAPATI, GANAPATI REDDY,RACHAKONDA, SUGUNA,ZHANG, HAI-REN,CHUN, BYOUNG-KWON,WANG, PEIYUAN

申请号：

PL11714465

公开号：

PL2552930T3

申请日:

2011.03.31

申请国别(地区):

PL

年份:

2016

代理人:

摘要：

Disclosed herein is a process for preparing an enantiomerically- or a diastereomerically enriched phosphorus-containing active, salt, or pharmaceutically acceptable salt thereof, of formula I-1 , which comprises the steps of: (a) reacting a protected or unprotected Active with a base to form a salt of said active and then reacting said salt with an enantiomerically- or a diastereomerically enriched compound of formula II-1 wherein the Active is a nucleoside, a nucleoside-analog, or a non-nucleoside.

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