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SÍNTESE ESTEREOSSELETIVA DE PRINCÍPIOS ATIVOS CONTENDO FÓSFORO
专利权人:
GILEAD PHARMASSET LLC
发明人:
MICHAEL JOSEPH SOFIA,GANAPATI REDDY PAMULAPATI,BRUCE S. ROSS,SUGUNARA CHAKONDA,HAI-REN ZHANG
申请号:
PT14163247
公开号:
PT2752422T
申请日:
2011.03.31
申请国别(地区):
PT
年份:
2017
代理人:
摘要:
Disclosed herein is a process for preparing an enantiomerically- or a diastereomerically enriched phosphorus-containing active, salt, or pharmaceutically acceptable salt thereof, of formula I-1 , which comprises the steps of: (a) reacting a protected or unprotected Active with a base to form a salt of said active and then reacting said salt with an enantiomerically- or a diastereomerically enriched compound of formula II-1 wherein the Active is a nucleoside, a nucleoside-analog, or a non-nucleoside.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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