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Acetylated fatty acid salicylates and their uses
专利权人:
Inc.;Catabasis Pharmaceuticals
发明人:
MILNE, Jill,JIROUSEK, Michael,BEMIS, Jean,SMITH, Jesse
申请号:
ES09790168
公开号:
ES2656793T3
申请日:
2009.07.08
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of Formula I, ** Formula ** 5 or a pharmaceutically acceptable salt, hydrate, solvate, enantiomer or stereoisomer thereof, wherein: R1, R2, R3 and R4 are each independently selected from the group consisting of H, Cl, F, CN, -NH (C1-C3 alkyl), -N (C1-C3 alkyl) 2, -NH (C (O) C1-C3 alkyl), -N (C (O) C1-C3 alkyl) 2, -C (O) H, -C (O) C1-C3 alkyl, -C (O) C1-C3 alkyl, -C (O) NH2, -C (O) NH (C1 alkyl -C3), -C (O) N (C1-C3 alkyl) 2, -O-C1-C3 alkyl, -S (O) C1-C3 alkyl and -S (O) 2-C1-C3 alkyl; W1 and W2 are each independently null, O or NH, or when W1 and W2 are both NH, then both W1 and W2 can be taken together to form a piperazine fraction; - - - - - represents an optional link that when present, it is necessary that Q be null; a and c are each independently H, CH3, -OCH3, -OCH2CH3 or C (O) OH; b is H, CH3, C (O) OH or O-Z; d is H or C (O) OH; each n, o, p and q is independently 0 or 1; each Z is H or ** Formula ** with the proviso that there is at least one ** Formula ** in the compound; each r is independently 2 or 3, and each s is independently 5 or 6; or each r is independently 7 and each s is independently 3; each t is independently 0 or 1; Q is null, C (O) CH3, Z,Un compuesto de Fórmula I,**Fórmula** 5 o una sal, un hidrato, un solvato, un enantiómero o un estereoisómero farmacéuticamente aceptables del mismo, en la que: R1, R2, R3 y R4 se seleccionan cada uno independientemente del grupo que consiste en H, Cl, F, CN, -NH(alquilo C1-C3), -N(alquilo C1-C3)2, -NH(C(O)alquilo C1-C3), -N(C(O)alquilo C1-C3)2, -C(O)H, -C(O)alquilo C1-C3, -C(O)Oalquilo C1-C3, -C(O)NH2, -C(O)NH(alquilo C1-C3), -C(O)N(alquilo C1-C3)2, -O-alquilo C1-C3, -S(O)alquilo C1-C3 y -S(O)2-alquilo C1-C3; W1 y W2 son cada uno independientemente nulos, O o NH, o cuando W1 y W2 son ambos NH, entonces tanto W1 como W2 se pueden tomar conjuntamente para formar una fracción de piperazina; - - - - - representa un enlace opcional que cuando está presente, es necesario que Q sea nulo; a y c son cada
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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