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Approach for synthesis of catechins
专利权人:
发明人:
Sundeep Dugar,Dinesh Mahajan,Kumar Santosh Rai,Vinayak Tripathi,Ishwar Rakesh Patil
申请号:
US14763018
公开号:
US09556140B2
申请日:
2014.01.27
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin (ii) reducing the penta-protected quercetin obtained from step (i) (iii) optionally deprotecting the compound of step (ii) (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.
来源网站:
中国工程科技知识中心
来源网址:
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