The present disclosure is to provide a method for producing superior denatured whey protein which does not adversely affect the properties of the product. Whey protein solution, the following (1) and (2) comparing the process for producing a modified whey proteins characterized continuously by repeatedly processed more than once. (1) 50 MPa or more, the step of pressurizing and heating treatment at 85 to 100 ° C., (2) the following pressurizing and heating treatment of (1), and vacuum treatment to 0.05 to 0.5 MPa, the step of maintaining the temperature in the range of ± 10 ℃ heating temperature of step (1).本開示は、製品の性質に好ましくない影響を与えないような優れた変性ホエイ蛋白質の製造方法を提供すること。ホエイ蛋白質溶液を、以下の(1)及び(2)の工程を連続的に2回以上繰り返して処理することを特徴とする変性ホエイ蛋白質の製造方法。 (1)50MPa以上、85~100℃で加圧加熱処理する工程、 (2)前記(1)の加圧加熱処理後に、0.05~0.5MPaに減圧処理し、前記(1)の工程の加熱温度の±10℃の範囲で温度を保持する工程。