BI, YINGZHI,毕映枝,畢映枝,CARSON, KENNETH GORDON,卡尔森肯尼士高登,卡爾森肯尼士高登,CIANCHETTA, GIOVANNI,钱切达乔伐尼,錢切達喬伐尼,GREEN, MICHAEL ALAN,葛林麦可亚伦,葛林麥可亞倫,KUMI, GODWIN,古米葛德温,古米葛德溫,LIANG, ZHI,梁智,梁智,LIU, YING JADE,刘瑛,劉瑛,MAIN, A
申请号：
TW102108279
公开号：
TW201341385A
申请日:
2013.03.08
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.本發明揭示一種具有以下化學式的咪唑[1,2-b]噠嗪基化合物:其中在本文中定義R1、R2與R3。本發明亦揭示包含該等化合物的組成物及使用該等組成物治療、管理及/或預防由AP2(adaptor)關聯激酶1活性介導之疾病與失調癥的方法。
