Jean-Pierre Andre Marc Bongartz,Lieven Meerpoel,Gustaaf Maria Boeckx,Guy Rosalia Eugeen Van Lommen,Christophe Francis Robert Nestor Buyck,Daniel Obrecht,Philipp Ermert,Anatol Luther
申请号：
US14456054
公开号：
US09120821B2
申请日:
2014.08.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention further relates to a DGAT inhibitor of formulaincluding any stereochemically isomeric form thereof, wherein A represents CH or N； X represents —NRx—C(═O)—； —Z—C(═O)—； —Z—NRx—C(═O)—； —S(═O)p-； —C(═S)—； —NRx—C(═S)—； —Z—C(═S)—； —Z—NRx—C(═S)—； —O—C(═O)—； —C(═O)—C(═O)—； R1 represents a 5-membered monocyclic heterocycle containing at least 2 heteroatoms； a 6-membered aromatic monocyclic heterocycle； or a 5-membered heterocycle containing at least 2 heteroatoms fused with phenyl, cyclohexyl or a 5- or 6-membered heterocycle； wherein each of said heterocycles may optionally be substituted； R2 represents R3； R3 represents C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzo-dioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or 6-membered aromatic heterocycle may optionally be substituted； a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof.The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.
