FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a compound of formulawherein Rrepresents hydrogen or Calkyl； Rrepresents groupsandor may be specified in a group consisting of, wherein Rrepresents hydrogen, halogen or aryl optionally substituted by halogen； X represents a bond, -(CH)-, -CHRCH-, -CHR(CH)-, -O-CHRCH- or -(Ccyclopropyl)-CH-CH-, and R represents Calkyl or Calkyl substituted by halogen； Rrepresents a) Calkyl； b) hydrogen； c) NH-phenyl optionally substituted by one or more substitutes specified in halogen or Calkyl substituted by halogen； d) NH-6-merous heteroaryl containing 1 or 2 heteroatoms N optionally substituted by one or more substitutes specified in halogen or C-alkyl substituted by halogen； e) (CR'R")-C-cycloalkyl optionally substituted by halogen, Calkyl, Calkyl substituted by halogen, halogen-substituted phenyl or heteroaryl, which represents pyridine； f) 6-merous heterocycloalkyl containing 1 or 2 heteroatoms specified in N and O, optionally substituted by halogen or Calkyl substituted by halogen； g) (CR'R")-5-6-merous monocyclic or 9-10-mrous bicyclic heteroaryl containing 1-3 heteroatoms specified in N, S and O, optionally substituted by halogen, Calkoxy, Calkyl, substituted by halogen, Calkoxy substituted by halogen, Calkyl, Ccycloalkyl, NHC(O)-Calkyl, cyano, S(O)-Calkyl, NRRor 5-6-merous heteroaryl containing 1 or 2 heteroatoms, N or 6-merous heterocyclyl containing 1 or 2 heteroatoms specified in N, O and S, wherein S is optionally specified by two oxygen molecules, which is optionally substituted by halogen； h) (CR'R")-phenyl optionally substituted by halogen, Calkyl substituted by halogen, C-alkoxy substituted by halogen, Calkyl, Calkinyl, Calkoxy, CH-Calkoxy or cyano； i) -O(CH)-phenyl optionally substituted by halogen, Calkoxy or Calkyl substituted by halogen； R' and R" independently represent hydrogen, Calkoxy or Calkyl； or together with atom C may form C-cycloalkyl group； Rrepresents phenyl or 10-merous heteroaryl contai
