Bonvini, Ezio,Koenig, Scott,Wilder, Ronald,Johnson, Leslie S.
申请号：
AU2013200924
公开号：
AU2013200924A1
申请日:
2013.02.15
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013200924A120130307.pdf#####ABSTRACT The present invention provides methods of treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. In particular, the methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the invention provides for modification of the anti-CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non- modified anti-CD3 antibodies.
