שימוש בנוגדנים מונוקלונלים נוגדי cd3 נבחרים מ– okt3, leu–4, 500a2, clbt–t3/3, m291, yth 12.5 או bma030 להכנת תרופה לטיפול בסוכרת סוג 1, פסוריאסיס או דלקת מפרקים שגרונית או להקל על הסימפטומים שלהם
The present invention provides methods of treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. In particular, the methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the invention provides for modification of the anti-CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non- modified anti-CD3 antibodies.
