Ezio Bonvini;Ronald Wilder;Leslie S. Johnson;Scott Koenig
发明人:
Scott Koenig,Ronald Wilder,Ezio Bonvini,Leslie S. Johnson
申请号：
US11485557
公开号：
US08663634B2
申请日:
2006.07.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides methods of treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. In particular, the methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the invention provides for modification of the anti-CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non-modified anti-CD3 antibodies.
