Disclosed are a positive pressure capsule and its manufacturing method. The method includes: injecting medicine to an opening of the capsule, and sealing air-tightly the capsule so as to form a positive pressure capsule with a space containing air inside. The positive pressure capsule is characterized in having a tightly sealed seam and being capable of filling up liquid powder medicine. The capsule can be a hard capsule made of gelatin or hydroxypropyl methyl cellulose (HPMC).本發明係關於一種正壓膠囊及其製造方法,係包括於膠囊開口處注入藥物,並將膠囊密封、內部含有氣體空間形成正壓膠囊。該正壓膠囊之特徵為密合接縫以及可充填液態粉末等藥物,該膠囊可為硬膠囊,原料可為明膠(gelatin)或羥丙基甲基纖維素(HPMC)。1‧‧‧膠囊囊體2‧‧‧膠囊內含正壓氣體或氣泡3‧‧‧膠囊囊體接合線5‧‧‧膠囊內部填充之藥物