In a positive pressure capsule and its manufacturing method, it includes injection of a drug through at the opening of the capsule followed by sealing the capsule and internal of the capsule contains air space so as to form a positive pressure capsule. The features of the positive pressure capsule are adhesion seams and liquid drugs can be filled inside such capsule. The capsule may be a hard capsule and the raw material of the capsule may be gelatin or HPMC.