The present teachings relate to compounds of Formula I:and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, andare as defined herein.The present teachings also provide methods of preparing compounds of FormulaIand methods of using compounds of FormulaIin treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.本發明陳述內容係關於式I化合物：及其藥學上可接受之鹽、水合物、酯及前體藥物，其中R1，R2,R3,Y,Z及均如本文定義。本發明陳述內容亦提供製備式I化合物之方法，及使用式I化合物於治療、抑制或預防整體或一部份藉由去乙醯酶所媒介之病理學症狀或病症之方法。
