新規カルボン酸誘導体およびプロドラッグ农业专利-农业学术服务平台

发明人:: IWABUCHI TAKEYUKI,岩渕剛行,YOSHINO YASUHIRO,吉野泰裕,MIYATA SAHO,宮田幸帆,KATO HIROSHIGE,加藤宏茂,AMADA JUNICHIRO,雨田淳一郎,OOKA YUKO,大岡祐子,WATANABE YOSUKE,渡邉洋祐,KAWASAKI NOBUHIDE,川崎伸英,KURITA NAOKI,栗田直樹,N

摘要：: PROBLEM TO BE SOLVED: To provide compounds which have antagonistic actions against prostaglandin E2 (PGE2) receptor subtype EP3 and are effective in preventing and/or treating various diseases associated with EP3 receptor operation.SOLUTION: Provided are compounds represented by the specified general formula (1), where R1, R2, R3, R4, R5 and A are defined in the specifications, pharmaceutically acceptable salts thereof, and hydrates and solvates of them.COPYRIGHT: (C)2014,JPO&INPIT【課題】プロスタグランジンE2(PGE2)受容体サブタイプEP3に対する拮抗作用を有し、EP3受容体の作動が関連する各種疾患の予防及び/又は治療に有効な化合物の提供。【解決手段】上記一般式(1)[上記式中、R1、R2、R3、R4、R5、Aの定義は明細書記載のとおり]で表される化合物、その医薬上許容される塩、並びにそれらの水和物及び溶媒和物。