The University of Tokyo;Nihon University;Institute Of Microbiology, Chinese Academy Of Sciences;Toray Industries, Inc.;Japan as Represented by Director-General of National Institute of Infectious
发明人:
申请号：
EP11759547.0
公开号：
EP2551345A1
申请日:
2011.03.25
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
An objective of this invention is to provide an HCV strain with a high capacity for virus production in a cell culture system. This invention provides a nucleic acid encoding a polyprotein precursor of the hepatitis C virus JFH1 strain having one or more amino acid substitutions, wherein the polyprotein precursor comprises at least substitution of glutamine at position 862 with arginine, as determined with reference to the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing.
