Infectious hepatitis C virus—high producing HCV variants and use thereof

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专利权人:

Yoshihiro Kitamura

发明人:

Yoshihiro Kitamura,Yoko Shimizu,Chie Aoki,Lijuan Yu,Takaji Wakita

申请号：

US13636904

公开号：

US09057048B2

申请日:

2011.03.25

申请国别(地区):

US

年份:

2015

代理人:

摘要：

An objective of this invention is to provide an HCV strain with a high capacity for virus production in a cell culture system. This invention provides a nucleic acid encoding a polyprotein precursor of the hepatitis C virus JFH1 strain having one or more amino acid substitutions, wherein the polyprotein precursor comprises at least substitution of glutamine at position 862 with arginine, as determined with reference to the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/