Yong Il Kim;Jong Soo Woo;Young Jun Na;Young-Hun Kim;Jae Hyun Park;Min Jung Kim
发明人:
Yong Il Kim,Young Jun Na,Min Jung Kim,Young-Hun Kim,Jae Hyun Park,Jong Soo Woo
申请号：
US13640590
公开号：
US20130028974A1
申请日:
2011.05.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided is a pharmaceutical formulation in the form of a bilayered tablet consisting of a first layer containing irbesartan or a pharmaceutically acceptable salt thereof and a second layer containing an HMG-CoA reductase inhibitor and a basic additive, which can improve the dissolution rate and stability of irbesartan and an HMG-CoA reductase inhibitor to enhance the bioavailability of the drug compared to conventional complex formulations and to minimize the generation of the related compounds, thereby being effectively used as a stable and superior therapeutic agent for hypertension and hypercholesterolemia.
