CONSTRUCTION OF NUCLEIC ACID, PLASMIDIAL TRANSFER VECTOR, TRANSFORMED CELLS, SPAM-VIRUS ZIKA VIRUSES (MV-ZIKV), COMPOSITION OR SET OF ACTIVE INGREDIENTS, AND PROCESS FOR RECOVERING VIRUS-VIRUSES
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT PASTEUR
发明人:
ETIENNE SIMON-LORIERE,FREDERIC TANGY
申请号：
BR112019025310
公开号：
BR112019025310A2
申请日:
2018.06.06
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention relates to recombinant measles viruses that express Zika virus proteins and their applications, particularly in inducing preventive protection against the Zika virus. the present invention is directed to the recombinant measles virus (mv) which expresses at least (i) the precursor of the membrane protein (prm) of a zika virus (zikv) and the envelope protein (e) of a zikv or a version truncated, or (ii) the protein and a zikv or a truncated version of the same, and concerns the recombinant infectious particles of said mv-zikv capable of replicating in a host after administration, and also concerns the particles similar to viruses (vlps) that contain these zikv proteins on their surfaces. the present invention provides means, particularly nucleic acids, vectors, cells and recovery systems for producing such recombinant infectious particles and vlps. the present invention also relates to the use of these recombinant infectious particles and / or vlps, in particular in the form of a composition, more particularly in a vaccine formulation, for the prevention of a zikv infection or for the preventive protection against outcomes clinical signs of zikv infection.a presente invenção refere-se aos vírus do sarampo recombinantes que expressam proteínas do vírus zika e suas aplicações, particularmente na indução da proteção preventiva contra o vírus zika. a presente invenção é direcionada ao vírus do sarampo recombinante (mv) que expressa pelo menos (i) o precursor da proteína de membrana (prm) de um vírus zika (zikv) e a proteína do envelope (e) de um zikv ou uma versão truncada da mesma, ou (ii) a proteína e de um zikv ou uma versão truncada da mesma, e diz respeito às partículas infecciosas recombinantes do referido mv-zikv capazes de se replicarem em um hospedeiro após a administração, e diz respeito também às partículas semelhantes a vírus (vlps) que contêm essas proteínas zikv em suas superfícies. a presente invenção fornece meios, particularmente ác
