AGONOX, INC.;PROVIDENCE HEALTH & SERVICES-OREGON;PROVIDENCE HEALTH & SERVICES - OREGON
发明人:
WEINBERG, ANDREW D.,MONTLER, RYAN,DUHEN, THOMAS,DUHEN, REBEKKA
申请号：
CA3061959
公开号：
CA3061959A1
申请日:
2018.05.04
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Methods are disclosed for treating a subject with a tumor. These methodsinclude administering to the subject atherapeutically effective amount of CD8+CD39+CD103+ T cells. Methods also aredisclosed for isolating a nucleic acid encoding a Tcell receptor (TCR) that specifically binds a tumor cell antigen. Thesemethods include isolating CD8+CD39+CD103+ T cells from asample from a subject with a tumor expressing the tumor cell antigen, andcloning a nucleic acid molecule encoding a TCR from theCD8+CD39+CD103+ T cells. In addition, methods are disclosed for expandingCD8+CD39+CD103+ T cells. In additionalembodiments, methods are disclosed for determining if a subject with a tumorwill respond to a checkpoint inhibitor. The methods includedetecting the presence of CD8+CD39+CD103+ T cells in a biological sample froma subject.
